Synthesis and biological evaluation of metallic compounds of Technetium-99m and Rhenium-188 for theranostic applications in Nuclear Medicine
Radiopharmaceuticals (RP) are drugs containing radioactive isotopes of certain elements, used in nuclear medicine for diagnosis and/or therapy. The systemic administration of 'target' specific RPs, which provides a specific distribution of the radionuclide to tumor sites is an interesting opportunity for the diagnosis and the therapy of tumors/metastases. The development of a 'target-specific' RP is conditioned by the availability of appropriate radionuclides, efficient labelling procedures that leaves unaltered the biological property of the native molecule and reliable targeting vector.
Copper (I) complexes as potential anticancer agents
Since the discovery of the antitumor activity of cisplatin cis-[PtCl2(NH3)2] for the treatment of several human tumors, thousands of platinum and other metal–based compounds have been tested for their potential antitumor properties in the last 40 years. Aim of this search is to overcome the drawbacks of Pt(II) derivatives such low specificity, high toxicity and inherited and/or acquired drug resistance.
- Study of environmental phenomena through radiochemical approach
- Studies of natural and artificial radionuclides mobility in the environment for their potential danger for man health or environment
- Development of radioanalytical methodologies and monitoring technologies